A headache is the most common side... more. Esomeprazole has an average rating of 5.9 out of 10 from a total of 267 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 37% reported a negative effect. Famotidine has an average rating of 4.3 out of 10 from a total of 170 ratings on Drugs.com. 33% of reviewers reported a ... Pepcid (famotidine) and Prilosec (omeprazole) are used to treat and prevent recurrence of stomach and duodenal ulcers. Pepcid is also useful in managing heartburn, gastroesophageal reflux disease ( GERD ), and Zollinger-Ellison syndrome. Pepcid and Prilosec belong to different drug classes.Nexium has an average rating of 6.1 out of 10 from a total of 209 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 36% reported a negative effect. Omeprazole has an average rating of 4.6 out of 10 from a total of 491 ratings on Drugs.com. 32% of reviewers reported a positive effect, while 53% reported a negative …

I take both. Omeprazole in the am and famotidine in the pm. Although will be weeningoff the omeprazole soon. My doc said the famotidine is safer for longer term use. I now have most of my reflux controlled by diet. I also take probiotics and digestive enzymes every day and that helps. 3.H2 blocker Tagamet HB (cimetidine) interacts with medications broken down by liver enzymes. Tagamet HB can increase the effects of some seizure medicines, heart medicines, and antidepressants. PPIs can decrease magnesium levels in the body, particularly if taken for over one year. Your healthcare provider may monitor your …

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